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Article Dans Une Revue Transplant International Année : 2021

Living kidney donor evaluation for all candidates with normal estimated GFR for age

1 CIC - CHU Bichat
2 CRI (UMR_S_1149 / ERL_8252 / U1149) - Centre de recherche sur l'Inflammation
3 CHU Nantes - Centre Hospitalier Universitaire de Nantes
4 HEGP - Hôpital Européen Georges Pompidou [APHP]
5 CHU Nice - Centre Hospitalier Universitaire de Nice
6 CHU - Hôpital Pasteur [Nice]
7 CHU Pitié-Salpêtrière [AP-HP]
8 Service de Néphrologie-Dialyse-Transplantation rénale [CHU Caen]
9 Hôpital Côte de Nacre [CHU Caen]
10 CHU Trousseau [Tours]
11 CHU Amiens-Picardie
12 Service de Néphrologie-transplantation-dialyse [Bordeaux]
13 ImmunoConcept - Immunology from Concept and Experiments to Translation
14 Hôpital Foch [Suresnes]
15 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
16 Service de Néphrologie [Rouen]
17 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
18 CHU Clermont-Ferrand
19 AP-HP - Hopital Saint-Louis [AP-HP]
20 IMRB - Institut Mondor de Recherche Biomédicale
21 Service de Néphrologie et Transplantation rénale [CHRU-lille]
22 INFINITE (Ex-Liric) - Institute for Translational Research in Inflammation - U 1286
23 Service de Néphrologie - Immunologie Clinique [Toulouse]
24 CPTP - Centre de Physiopathologie Toulouse Purpan
25 CHU - BREST - Hopital de Bohars - CHRU Brest
26 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
27 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
28 Hôpital Necker - Enfants Malades [AP-HP]
29 APHM - Assistance Publique - Hôpitaux de Marseille
30 MEPHI - Microbes évolution phylogénie et infections
31 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
32 CHU Dijon
33 HCL - Hospices Civils de Lyon
34 UCBL - Université Claude Bernard Lyon 1
35 Hôpital universitaire Robert Debré [Reims]
36 CHU Tenon [AP-HP]
37 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
38 CHU de Poitiers - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
39 IRTOMIT - Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques
40 CHU Limoges
41 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
42 CHU Nîmes - Hôpital Universitaire Carémeau [Nîmes]
43 Université de Liège
44 INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades
45 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
46 Université de Lyon
Benoit Barrou
  • Fonction : Auteur
  • PersonId : 918714
Dimitri Titeca-Beauport
Luc Frimat
  • Fonction : Auteur
  • PersonId : 759372
  • IdRef : 113414099
Cyril Garrouste
Alexandre Hertig
Christiane Mousson
Nacera Ouali
  • Fonction : Auteur
Fatouma Toure
  • Fonction : Auteur

Résumé

Multiple days assessments are frequent for the evaluation of candidates to living kidney donation, combined with an early GFR estimation (eGFR). Living kidney donation is questionable when eGFR is <90 ml/min/1.73 m2 (KDIGO guidelines) or 80 ml/min/1.73 m2 (most US centres). However, age-related GFR decline results in a lower eGFR for older candidates. That may limit the number of older kidney donors. Yet, continuing the screening with a GFR measure increases the number of eligible donors. We hypothesized that in-depth screening should be proposed to all candidates with a normal eGFR for age. We compared the evolution of eGFR after donation between three groups of predonation eGFR: normal for age (Sage ) higher than 90 or 80 ml/min/1.73 m2 (S90 and S80, respectively); across three age groups (<45, 45-55, >55 years) in a population of 1825 French living kidney donors with a median follow-up of 5.9 years. In donors younger than 45, postdonation eGFR, absolute- and relative-eGFR variation were not different between the three groups. For older donors, postdonation eGFR was higher in S90 than in S80 or Sage but other comparators were identical. Postdonation eGFR slope was comparable between all groups. Our results are in favour of in-depth screening for all candidates to donation with a normal eGFR for age.

Domaines

Chirurgie

Dates et versions

hal-03665050 , version 1 (11-05-2022)

Licence

Paternité

Identifiants

Citer

F. Gaillard, Lola Jacquemont, Hélène Lazareth, Laetitia Albano, Benoit Barrou, et al.. Living kidney donor evaluation for all candidates with normal estimated GFR for age. Transplant International, 2021, 34 (6), pp.1123-1133. ⟨10.1111/tri.13870⟩. ⟨hal-03665050⟩
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