Ischémie reperfusion en transplantation rénale - Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques Accéder directement au contenu
Article Dans Une Revue Néphrologie & Thérapeutique Année : 2020

Ischémie reperfusion en transplantation rénale

Résumé

Ischemia-reperfusion injury is an inescapable phenomenon in kidney transplantation. It combines lesional processes of biochemical origin associated with oxydative stress and of immunological origin in connection with the recruitment and activation of innate immunity cells. Histological lesions associate acute tubular necrosis and interstitial œdema, which can progress to interstitial fibrosis. The extent of these lesions depends on donor characteristics (age, expanded criteria donor, etc.) and cold ischemia time. In the short term, ischemia-reperfusion results in delayed recovery of graft function. Cold ischemia time also impacts long-term graft survival. Preclinical models, such as murine and porcine models, have furthered understanding of the pathophysiological mechanisms of ischemia-reperfusion injury. Due to its renal anatomical proximity to humans, the porcine model is relevant to assessment of the molecules administered to a donor or recipient, and also of additives to preservation solutions. Different donor resuscitation and graft perfusion strategies can be studied. In humans, prevention of ischemia-reperfusion injury is a research subject as concerns donor conditioning, additive molecules in preservation solutions, graft reperfusion modalities and choice of the molecules administered to the recipient. Pending significant advances in research, the goal is to achieve the shortest possible cold ischemia time.
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Dates et versions

hal-03493388 , version 1 (21-11-2022)

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Paternité - Pas d'utilisation commerciale

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Léa Dufour, Maroua Ferhat, Aurélie Robin, Sofiane Inal, Frédéric Favreau, et al.. Ischémie reperfusion en transplantation rénale. Néphrologie & Thérapeutique, 2020, 16, pp.388 - 399. ⟨10.1016/j.nephro.2020.05.001⟩. ⟨hal-03493388⟩
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