Regulatory identification of BPA as an endocrine disruptor : Context and methodology - MULTIGNER-QUENEL - Evaluation des expositions et recherche épidémiologique sur l'environnement, la reproduction et le développement (3ERD) Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Molecular and Cellular Endocrinology Année : 2018

Regulatory identification of BPA as an endocrine disruptor : Context and methodology

Jean-Pierre Cravedi
  • Fonction : Auteur
Martine Kolf-Clauw
  • Fonction : Auteur
François Pouzaud
  • Fonction : Auteur
  • PersonId : 1303009
Christophe Rousselle
Cecile Michel
  • Fonction : Auteur

Résumé

BPA is one of the most investigated substances for its endocrine disruptor (ED) properties and it is at the same time in the center of many ED-related controversies, the analysis on how BPA fits to the regulatory identification as an ED is a challenge in terms of methodology. It is also a great opportunity to test the regulatory framework with a uniquely data-rich substance and learn valuable lessons for future cases. From this extensive database, it was considered important to engage in a detailed analysis so as to provide specific and strong evidences of ED while reflecting accurately the complexity of the response as well the multiplicity of adverse effects. An appropriate delineation of the scope of the analysis was therefore critical. Four effects namely, alterations of estrous cyclicity, mammary gland development, brain development and memory function, and metabolism, were considered to provide solid evidence of ED-mediated effects of BPA.

Domaines

Toxicologie
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Dates et versions

hal-01864338 , version 1 (18-09-2018)

Licence

Paternité - Pas d'utilisation commerciale

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Claire Beausoleil, Claude Emond, Jean-Pierre Cravedi, Jean-Philippe Antignac, Martine Applanat, et al.. Regulatory identification of BPA as an endocrine disruptor : Context and methodology. Molecular and Cellular Endocrinology, 2018, 475, pp.4-9. ⟨10.1016/j.mce.2018.02.001⟩. ⟨hal-01864338⟩
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