Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers. - MULTIGNER-QUENEL - Evaluation des expositions et recherche épidémiologique sur l'environnement, la reproduction et le développement (3ERD) Accéder directement au contenu
Article Dans Une Revue Environment International Année : 2014

Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers.

Mark Nieuwenhuijsen
David Martínez
  • Fonction : Auteur
Ferran Ballester
Mikel Basterrechea
  • Fonction : Auteur
Leda Chatzi
  • Fonction : Auteur
Mariana F Fernandez
  • Fonction : Auteur
Eva Govarts
  • Fonction : Auteur
Mònica Guxens
Joan O Grimalt
  • Fonction : Auteur
Monika Kasper-Sonnenberg
  • Fonction : Auteur
Lubica Palkovicova
  • Fonction : Auteur
Ulrich Ranft
  • Fonction : Auteur
Greet Schoeters
  • Fonction : Auteur
Maties Torrent
  • Fonction : Auteur
Damaskini Valvi
  • Fonction : Auteur
Nynke Weisglas-Kuperus
  • Fonction : Auteur
Michael Wilhelm
  • Fonction : Auteur
Jürgen Wittsiepe
  • Fonction : Auteur
Martine Vrijheid

Résumé

Low-level exposure to polychlorinated biphenyl-153 (PCB-153) and dichlorodiphenyldichloroethylene (p-p'-DDE) can impair fetal growth; however, the exposure-response relationship and effect modifiers of such association are not well established. This study is an extension of an earlier European meta-analysis. Our aim was to explore exposure-response relationship between PCB-153 and p-p'-DDE and birth outcomes; to evaluate whether any no exposure-effect level and susceptible subgroups exist; and to assess the role of maternal gestational weight gain (GWG). We used a pooled dataset of 9377 mother-child pairs enrolled in 14 study populations from 11 European birth cohorts. General additive models were used to evaluate the shape of the relationships between organochlorine compounds and birth outcomes. We observed an inverse linear exposure-response relationship between prenatal exposure to PCB-153 and birth weight [decline of 194g (95% CI -314, -74) per 1μg/L increase in PCB-153]. We showed effects on birth weight over the entire exposure range, including at low levels. This reduction seems to be stronger among children of mothers who were non-Caucasian or had smoked during pregnancy. The most susceptible subgroup was girls whose mothers smoked during pregnancy. After adjusting for absolute GWG or estimated fat mass, a reduction in birth weight was still observed. This study suggests that the association between low-level exposure to PCB-153 and birth weight exists and follows an inverse linear exposure-response relationship with effects even at low levels, and that maternal smoking and ethnicity modify this association.

Dates et versions

hal-01118572 , version 1 (19-02-2015)

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Citer

Maribel Casas, Mark Nieuwenhuijsen, David Martínez, Ferran Ballester, Xavier Basagaña, et al.. Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers.. Environment International, 2014, 74, pp.23-31. ⟨10.1016/j.envint.2014.09.013⟩. ⟨hal-01118572⟩
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