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Article Dans Une Revue Genetika / Russian Journal of Genetics Année : 2022

The Length of Telomeres and the Baseline Level of Cytogenetic Damage in Leukocytes of Lung Cancer Patients

Résumé

Abstract: Despite the great efforts of basic and clinical research on lung cancer (LC), the prevention and treatment of this type of cancer show still far from satisfactory indicators. The complex mechanisms of the LC biology are already recognized, but there is a significant gap in the knowledge about the interaction of key biomarkers in the etiology and progression of this disease. The present work is aimed at studying the relationship between the telomere length (TL) and frequencies of chromosomal aberrations (CA) and micronuclei (MN) in leukocytes of primary lung cancer patients. In 67 men with lung cancer and 77 control donors (men), the baseline frequencies of CA and MN were determined in blood leukocytes, and TL was also studied. As a result, a significant increase in TL was found in lung cancer patients compared with control donors (25.86 ± 2.13 versus 15.29 ± 1.22, respectively, p = 0.00001). In leukocytes of LC patients, a significant increase in the baseline level of structural aberrations of chromosomes, as well as micronuclei containing centromeres, was noted. Only in the sample of lung cancer patients were direct correlations of TL with the frequency of chromosomal type aberrations and with the frequency of paired fragments revealed. In the same sample, significant inverse correlations of TL with the frequency of binucleated leukocytes containing nuclear protrusions and with the frequency of cells entering apoptosis were recorded. The study first showed that an increase in TL in lung cancer patients is associated with structural chromosomal damages, but not with the incidence of aneuploidies.
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Dates et versions

hal-03719726 , version 1 (19-07-2022)

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V.G. Druzhinin, E Baranova, V.P. Volobaev, V.I. Ivanov, A.V. Larionov, et al.. The Length of Telomeres and the Baseline Level of Cytogenetic Damage in Leukocytes of Lung Cancer Patients. Genetika / Russian Journal of Genetics, 2022, 58 (1), pp.73-84. ⟨10.1134/S1022795422010021⟩. ⟨hal-03719726⟩
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