Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients - Individual Prediction and Prevention of Risks of Immunosuppressive Therapies in Transplantation Access content directly
Journal Articles Liver Transplantation Year : 2018

Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients

1 ANTICIPE - Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers
2 Hôpital Côte de Nacre [CHU Caen]
3 CHU Caen
4 HCL - Hospices Civils de Lyon
5 CHU Trousseau [Tours]
6 IP - Institut Pascal
7 CHU Estaing [Clermont-Ferrand]
8 Hôpital Edouard Herriot [CHU - HCL]
9 CHU Pitié-Salpêtrière [AP-HP]
10 Pathologies biliaires, fibrose et cancer du foie [CRSA]
11 Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges]
12 PIST - Pharmacologie des Immunosuppresseurs et de la Transplantation
13 Hôpital Necker - Enfants Malades [AP-HP]
14 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
15 Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM]
16 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
17 LIRIC - Lille Inflammation Research International Center - U 995
18 CRI (UMR_S_1149 / ERL_8252 / U1149) - Centre de recherche sur l'Inflammation
19 CHU Henri Mondor [Créteil]
20 CHU Nice - Centre Hospitalier Universitaire de Nice
21 TIMONE - Hôpital de la Timone [CHU - APHM]
22 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
23 ICPH - Intéractions cellulaires et physiopathologie hépatique (Orsay, Essonne) UMRS 1174
24 Service de Néphrologie - Hypertension Artérielle Dialyse - Transplantation
25 Equipe EPICAD (LNC - U1231)
26 Service d'hépato-gastroentérologie et cancérologie digestive (CHU de Dijon)
27 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
28 Hôpital Haut-Lévêque [CHU Bordeaux]
29 CHRU Montpellier - Hôpital Saint Eloi
30 CHB - Centre hépato-biliaire
31 Physiopathologie et traitement des maladies du foie
32 Service d'hépatologie
33 Pôle des Pathologies Digestives Hépatiques et Transplantation [Hôpital Hautepierre-Strasbourg]
Thierry Lobbedez
Armand Abergel
Georges-Philippe Pageaux
Sylvie Radenne

Abstract

De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biomédecine database, the present study aimed to quantify the risk of solid organ de novo malignancies (excluding nonmelanoma skin cancers) after LT. The incidence of de novo malignancies among all LT patients between 1993 and 2012 was compared with that of the French population, standardized on age, sex, and calendar period (standardized incidence ratio; SIR). Among the 11,226 LT patients included in the study, 1200 de novo malignancies were diagnosed (10.7%). The risk of death was approximately 2 times higher in patients with de novo malignancy (48.8% versus 24.3%). The SIR for all de novo solid organ malignancies was 2.20 (95% confidence interval [CI], 2.08‐2.33). The risk was higher in men (SIR = 2.23; 95% CI, 2.09‐2.38) and in patients transplanted for alcoholic liver disease (ALD; SIR = 2.89; 95% CI, 2.68‐3.11). The cancers with the highest excess risk were laryngeal (SIR = 7.57; 95% CI, 5.97‐9.48), esophageal (SIR = 4.76; 95% CI, 3.56‐6.24), lung (SIR = 2.56; 95% CI, 2.21‐2.95), and lip‐mouth‐pharynx (SIR = 2.20; 95% CI, 1.72‐2.77). In conclusion, LT recipients have an increased risk of de novo solid organ malignancies, and this is strongly related to ALD as a primary indication for LT.

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Cancer
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Dates and versions

hal-02000599 , version 1 (30-01-2019)

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Olivier Sérée, Mario Altieri, Elodie Guillaume, Rémy de Mil, Thierry Lobbedez, et al.. Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients. Liver Transplantation, 2018, 24 (10), pp.1425-1436. ⟨10.1002/lt.25310⟩. ⟨hal-02000599⟩
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