B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors. - Individual Prediction and Prevention of Risks of Immunosuppressive Therapies in Transplantation Access content directly
Journal Articles Cellular and Molecular Life Sciences Year : 2011

B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors.

Abstract

Natural killer (NK) cells are lymphocytes of the innate immune system that sense target cells through a panel of activating and inhibitory receptors. Together with NKG2D, the natural cytotoxicity receptors (NCRs) are major activating receptors involved in tumor cell detection. Although numerous NKG2D ligands have been identified, characterization of the molecules interacting with the NCRs is still incomplete. The identification of B7-H6 as a counter structure of the NCR NKp30 shed light on the molecular basis of NK cell immunosurveillance. We review here the current knowledge on NKp30 and B7-H6, and we discuss their potential role in anti-tumor immunity.

Domains

Immunology

Dates and versions

hal-00667776 , version 1 (08-02-2012)

Identifiers

Cite

Tomonori Kaifu, Bertrand Escalière, Louis Noël Gastinel, Eric Vivier, Myriam Baratin. B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors.. Cellular and Molecular Life Sciences, 2011, 68 (21), pp.3531-9. ⟨10.1007/s00018-011-0802-7⟩. ⟨hal-00667776⟩
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