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TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence

Valerio Farfariello , Dmitri Gordienko , Lina Mesilmany , Yasmine Touil , Emmanuelle Germain et al.
Nature Communications, 2022, 13 (1), pp.956. ⟨10.1038/s41467-022-28597-x⟩
Journal articles hal-03666578v1

Intratumoural spatial distribution of S100B + folliculostellate cells is associated with proliferation and expression of FSH and ERα in gonadotroph tumours

Mirela Diana Ilie , Alexandre Vasiljevic , Marie Chanal , Nicolas Gadot , Laura Chinezu et al.
Acta Neuropathologica Communications, 2022, 10 (1), pp.18. ⟨10.1186/s40478-022-01321-y⟩
Journal articles hal-03666692v1

Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cells

Alberta Palazzo , Hector Hernandez-Vargas , Delphine Goehrig , Jean-Jacques Médard , David Vindrieux et al.
Cancer Letters, 2022, 546, pp.215850. ⟨10.1016/j.canlet.2022.215850⟩
Journal articles hal-03777234v1

Expression of the Calcium-Binding Protein CALB1 Is Induced and Controls Intracellular Ca2+ Levels in Senescent Cells

Clotilde Raynard , Nolwenn Tessier , Anda Huna , Marine Warnier , Jean-Michel Flaman et al.
International Journal of Molecular Sciences, 2022, 23 (16), pp.9376. ⟨10.3390/ijms23169376⟩
Journal articles hal-03777244v1
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NF‐κB‐dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cells

Clotilde Raynard , Xingjie Ma , Anda Huna , Nolwenn Tessier , Amélie Massemin et al.
Aging Cell, 2022, 21 (7), ⟨10.1111/acel.13632⟩
Journal articles hal-03704116v1

Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

Michèle Mg Hillege , Andi Shi , Ricardo Galli , Gang Wu , Philippe Bertolino et al.
eLife, 2022, 11, ⟨10.7554/eLife.77610⟩
Journal articles hal-03766456v1

Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells

Nele Wagener , Malte Buchholz , Philippe Bertolino , Chang Zhang , Pietro Di Fazio et al.
Apoptosis, 2022, 27 (1-2), pp.70-79. ⟨10.1007/s10495-021-01700-1⟩
Journal articles hal-03666683v1

The scaffold protein menin is essential for activating the MYC locus and MYC‐mediated androgen receptor transcription in androgen receptor‐dependent prostate cancer cells

Yakun Luo , Virginie Vlaeminck‐guillem , Romain Teinturier , Razan Abou Ziki , Philippe Bertolino et al.
Cancer Communications, 2021, 41 (12), pp.1427-1430. ⟨10.1002/cac2.12217⟩
Journal articles hal-03666677v1
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The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor

Marie-Lise Lacombe , Frederic Lamarche , Olivier de Wever , Teresita Padilla-Benavides , Alyssa Carlson et al.
BMC Biology, 2021, 19 (1), ⟨10.1186/s12915-021-01155-5⟩
Journal articles hal-03403979v1

Reduced menin expression leads to decreased ERα expression and is correlated with the occurrence of human luminal B-like and ER-negative breast cancer subtypes

Romain Teinturier , Razan Abou Ziki , Loay Kassem , Yakun Luo , Lucie Malbeteau et al.
Breast Cancer Research and Treatment, 2021, 190 (3), pp.389-401. ⟨10.1007/s10549-021-06339-9⟩
Journal articles hal-03666672v1

Cellular senescence links mitochondria-ER contacts and aging

Dorian Ziegler , Nadine Martin , David Bernard
Communications Biology, 2021, 4 (1), pp.1323. ⟨10.1038/s42003-021-02840-5⟩
Journal articles hal-03666551v1

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Christos Karampelias , Habib Rezanejad , Mandy Rosko , Likun Duan , Jing Lu et al.
Nature Communications, 2021, 12 (1), pp.3362. ⟨10.1038/s41467-021-23673-0⟩
Journal articles hal-03666669v1
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Evidence that SARS-CoV-2 Induces Lung-Cell Senescence: Potential Impact on COVID-19 Lung Disease

Larissa Lipskaia , Pauline Maisonnasse , Charles Fouillade , Valentin Sencio , Quentin Pascal et al.
American Journal of Respiratory Cell and Molecular Biology, 2021, ⟨10.1165/rcmb.2021-0205le⟩
Journal articles hal-03395181v1
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Phospholipase A2 receptor 1 promotes lung cell senescence and emphysema in obstructive lung disease

Delphine Beaulieu , Aya Attwe , Marielle Breau , Larissa Lipskaia , Elisabeth Marcos et al.
European Respiratory Journal, 2021, 58 (2), pp.2000752. ⟨10.1183/13993003.00752-2020⟩
Journal articles inserm-03420591v1
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Elimination of Senescent Endothelial Cells: Good or Bad Idea?

Nadine Martin , Anda Huna , David Bernard
Trends in Cell Biology, 2021, 31 (5), pp.327-330. ⟨10.1016/j.tcb.2021.02.009⟩
Journal articles inserm-03420580v1

Stroma Involvement in Pancreatic Ductal Adenocarcinoma: An Overview Focusing on Extracellular Matrix Proteins

Sophie Liot , Jonathan Balas , Alexandre Aubert , Laura Prigent , Perrine Mercier-Gouy et al.
Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.612271⟩
Journal articles hal-03281971v1
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Loss of the Metastasis Suppressor NME1, But Not of Its Highly Related Isoform NME2, Induces a Hybrid Epithelial–Mesenchymal State in Cancer Cells

Anda Huna , Béatrice Nawrocki-Raby , Teresita Padilla-Benavides , Julie Gavard , Sylvie Coscoy et al.
International Journal of Molecular Sciences, 2021, 22 (7), pp.3718. ⟨10.3390/ijms22073718⟩
Journal articles inserm-03191241v1
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Extracellular AGR2 triggers lung tumour cell proliferation through repression of p21(CIP1)

Delphine Fessart , Claire de Barbeyrac , Ines Boutin , Thomas Grenier , Elodie Richard et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 2021, 1868 (3), pp.118920. ⟨10.1016/j.bbamcr.2020.118920⟩
Journal articles hal-03102260v1

Men1 disruption in Nkx3.1-deficient mice results in ARlow/CD44+ microinvasive carcinoma development with the dysregulated AR pathway

Romain Teinturier , Yakun Luo , Myriam Decaussin-Petrucci , Virginie Vlaeminck-Guillem , Francis Vacherot et al.
Oncogene, 2021, 40 (6), pp.1118-1127. ⟨10.1038/s41388-020-01589-1⟩
Journal articles hal-03666659v1
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PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging

Anda Huna , Audrey Griveau , David Vindrieux , Sara Jaber , Jean-Michel Flaman et al.
Cell Death and Disease, 2021, 12 (2), pp.190. ⟨10.1038/s41419-021-03468-3⟩
Journal articles inserm-03420490v1
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Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging

D. V. Ziegler , D. Vindrieux , D. Goehrig , S. Jaber , G. Collin et al.
Nature Communications, 2021, 12 (1), pp.720. ⟨10.1038/s41467-021-20993-z⟩
Journal articles inserm-03282710v1

Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis

Hélène Lasolle , Mad-Hélénie Elsensohn , Anne Wierinckx , Eudeline Alix , Clément Bonnefille et al.
Acta Neuropathologica Communications, 2020, 8 (1), pp.190. ⟨10.1186/s40478-020-01067-5⟩
Journal articles hal-03666649v1

Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A

Yajie Zhao , Zhichong Wu , Marie Chanal , Fabienne Guillaumond , Delphine Goehrig et al.
Cancer Research, 2020, 80 (16), pp.3359-3371. ⟨10.1158/0008-5472.CAN-19-3763⟩
Journal articles hal-03008999v1
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Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

Kevin Berthenet , Camila Castillo Ferrer , Deborah Fanfone , Nikolay Popgeorgiev , David Neves et al.
Cell Reports, 2020, 31 (10), pp.107731. ⟨10.1016/j.celrep.2020.107731⟩
Journal articles hal-02999426v1
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Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1

Sara Jaber , Delphine Goehrig , Philippe Bertolino , Amélie Massemin , Franck Bihl et al.
Scientific Reports, 2020, 10 (1), pp.8190. ⟨10.1038/s41598-020-64863-y⟩
Journal articles inserm-02865473v1
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The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes

Audrey Griveau , Clotilde Wiel , Dorian Ziegler , Martin Bergo , David Bernard et al.
Aging Cell, 2020, 19 (4), ⟨10.1111/acel.13122⟩
Journal articles hal-03009024v1
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Cardiac Glycosides as Senolytic Compounds

Nadine Martin , Olivier Soriani , David Bernard
Trends in Molecular Medicine, 2020, 26 (3), pp.243-245. ⟨10.1016/j.molmed.2020.01.001⟩
Journal articles hal-03009048v1
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Le traitement antioxydant protège contre l’emphysème mais favorise la survenue et la progression du cancer du poumon

Marielle Breau , David Bernard , Fatima Mechta-Grigoriou , Serge Adnot
médecine/sciences, 2020, 36 (3), pp.200-203. ⟨10.1051/medsci/2020030⟩
Journal articles hal-02903958v1
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Hepatic Stellate Cell Senescence in Liver Tumorigenesis

Nadine Martin , Dorian Ziegler , Romain Parent , David Bernard
Hepatology, In press, ⟨10.1002/hep.31556⟩
Journal articles hal-03008992v1

The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice

Marielle Breau , Amal Houssaini , Larissa Lipskaia , Shariq Abid , Emmanuelle Born et al.
JCI Insight, 2019, 4 (19), ⟨10.1172/jci.insight.127647⟩
Journal articles hal-02438202v1