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Article Dans Une Revue Psychological Medicine Année : 2023

Clinical features and outcomes of COVID-19 patients hospitalized for psychiatric disorders: a French multi-centered prospective observational study

1 NCPS - Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie
2 CPN - Centre Psychothérapique de Nancy [Laxou]
3 Faculté de Médecine [Nancy]
4 APEMAC - Adaptation, mesure et évaluation en santé. Approches interdisciplinaires
5 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
6 HCL - Hospices Civils de Lyon
7 GHU Paris Psychiatrie et Neurosciences
8 IGF - Institut de Génomique Fonctionnelle
9 Département de psychiatrie adulte
10 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
11 CESP - Centre de recherche en épidémiologie et santé des populations
12 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
13 ISTS - Imagerie et Stratégies Thérapeutiques de la Schizophrénie
14 Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes]
15 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
16 Centre Hospitalier le Vinatier [Bron]
17 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
18 IMRB - Institut Mondor de Recherche Biomédicale
19 CHR Metz-Thionville - Centre hospitalier régional Metz-Thionville
20 U894 - Centre de Psychiatrie et Neurosciences
21 CMME - Service de psychiatrie - Clinique des maladies mentales et de l'encéphale
22 Service Psychiatrie et psychologie médicale [CHU Toulouse]
23 ToNIC - Toulouse NeuroImaging Center
24 Centre Hospitalier Gérard Marchant
25 LilNCog - Lille Neurosciences & Cognition - U 1172
26 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
William Lecoeur
  • Fonction : Auteur
Wanda Yekhlef
  • Fonction : Auteur
Marion Leboyer
Pierre Thomas

Résumé

Background: Patients with psychiatric disorders are exposed to high risk of COVID-19 and increased mortality. In this study, we set out to assess the clinical features and outcomes of patients with current psychiatric disorders exposed to COVID-19. Methods: This multi-center prospective study was conducted in 22 psychiatric wards dedicated to COVID-19 inpatients between 28 February and 30 May 2020. The main outcomes were the number of patients transferred to somatic care units, the number of deaths, and the number of patients developing a confusional state. The risk factors of confusional state and transfer to somatic care units were assessed by a multivariate logistic model. The risk of death was analyzed by a univariate analysis. Results: In total, 350 patients were included in the study. Overall, 24 (7%) were transferred to medicine units, 7 (2%) died, and 51 (15%) patients presented a confusional state. Severe respiratory symptoms predicted the transfer to a medicine unit [odds ratio (OR) 17.1; confidence interval (CI) 4.9-59.3]. Older age, an organic mental disorder, a confusional state, and severe respiratory symptoms predicted mortality in univariate analysis. Age >55 (OR 4.9; CI 2.1-11.4), an affective disorder (OR 4.1; CI 1.6-10.9), and severe respiratory symptoms (OR 4.6; CI 2.2-9.7) predicted a higher risk, whereas smoking (OR 0.3; CI 0.1-0.9) predicted a lower risk of a confusional state. Conclusion: COVID-19 patients with severe psychiatric disorders have multiple somatic comorbidities and have a risk of developing a confusional state. These data underline the need for extreme caution given the risks of COVID-19 in patients hospitalized for psychiatric disorders.
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hal-03224998 , version 1 (25-10-2021)

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Daniela Dobre, Raymund Schwan, Claire Jansen, Thomas Schwitzer, Olivier Martin, et al.. Clinical features and outcomes of COVID-19 patients hospitalized for psychiatric disorders: a French multi-centered prospective observational study. Psychological Medicine, 2023, 53 (2), pp.342-350. ⟨10.1017/S0033291721001537⟩. ⟨hal-03224998⟩
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