Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study. - Comportement et noyaux gris centraux EA4712 Accéder directement au contenu
Article Dans Une Revue Neurology Année : 2014

Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study.

Résumé

Objective - The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. Methods - To resolve this issue, we set out to identify preoperative metabolic patterns and sociodemographic and clinical factors associated with increased apathy after STN-DBS. Forty-four patients with Parkinson disease were enrolled in this study. They all underwent STN-DBS. Metabolic activity was assessed with F-18 fluorodeoxyglucose PET 3 months before surgery. Apathy was assessed on the Apathy Evaluation Scale 3 months before and after STN-DBS. We controlled for preoperative age, levodopa therapy, and overall cognitive functions. Results - Increased apathy after STN-DBS was significantly associated with reduced preoperative metabolism within the right ventral striatum. None of the sociodemographic and clinical variables tested were associated with apathy after STN-DBS. Conclusions - Preoperative PET, but not sociodemographic or clinical factors, is associated with apathy after STN-DBS.
Fichier non déposé

Dates et versions

hal-01133830 , version 1 (20-03-2015)

Identifiants

Citer

Gabriel H Robert, Florence Le Jeune, Clement Lozachmeur, Sophie Drapier, Thibaut Dondaine, et al.. Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study.. Neurology, 2014, 83 (18), pp.1620-6. ⟨10.1212/WNL.0000000000000941⟩. ⟨hal-01133830⟩
47 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More