Predictive Value of Imaging Markers at Multiple Sclerosis Disease Onset Based on Gadolinium- and USPIO-Enhanced MRI and Machine Learning - CIC-Rennes Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2014

Predictive Value of Imaging Markers at Multiple Sclerosis Disease Onset Based on Gadolinium- and USPIO-Enhanced MRI and Machine Learning

Résumé

OBJECTIVES: A novel characterization of Clinically Isolated Syndrome (CIS) patients according to lesion patterns is proposed. More specifically, patients are classified according to the nature of inflammatory lesions patterns. It is expected that this characterization can infer new prospective figures from the earliest imaging signs of Multiple Sclerosis (MS), since it can provide a classification of different types of lesions across patients. METHODS: The method is based on a two-tiered classification. Initially, the spatio-temporal lesion patterns are classified. The discovered lesion patterns are then used to characterize groups of patients. The patient groups are validated using statistical measures and by correlations at 24-month follow-up with hypointense lesion loads. RESULTS: The methodology identified 3 statistically significantly different clusters of lesion patterns showing p-values smaller than 0.01. Moreover, these patterns defined at baseline correlated with chronic hypointense lesion volumes by follow-up with an [Formula: see text] score of [Formula: see text]. CONCLUSIONS: The proposed methodology is capable of identifying three major different lesion patterns that are heterogeneously present in patients, allowing a patient classification using only two MRI scans. This finding may lead to more accurate prognosis and thus to more suitable treatments at early stage of MS.
Fichier principal
Vignette du fichier
journal.pone.0093024.PDF (777 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-00971524 , version 1 (04-10-2018)

Licence

Paternité

Identifiants

Citer

Alessandro Crimi, Olivier Commowick, Adil Maarouf, Jean-Christophe Ferré, Elise Bannier, et al.. Predictive Value of Imaging Markers at Multiple Sclerosis Disease Onset Based on Gadolinium- and USPIO-Enhanced MRI and Machine Learning. PLoS ONE, 2014, 9 (4), pp.e93024. ⟨10.1371/journal.pone.0093024⟩. ⟨hal-00971524⟩
468 Consultations
241 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More